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Conformational Changes in the Lower Palm Domain of ASIC1a Contribute to Desensitization and RFamide Modulation
Acid-sensing ion channel 1a (ASIC1a) is a proton-gated cation channel that contributes to fear and pain as well as neuronal damage following persistent cerebral acidosis. Neuropeptides can affect acid-induced neuronal injury by altering ASIC1a inactivation and/or steady-state desensitization. Yet, e...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743763/ https://www.ncbi.nlm.nih.gov/pubmed/23977127 http://dx.doi.org/10.1371/journal.pone.0071733 |