Cargando…

Loss of the Anorexic Response to Systemic 5-Aminoimidazole-4-Carboxamide-1-β-D-Ribofuranoside Administration Despite Reducing Hypothalamic AMP-Activated Protein Kinase Phosphorylation in Insulin-Deficient Rats

This study tested whether chronic systemic administration of 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) could attenuate hyperphagia, reduce lean and fat mass losses, and improve whole-body energy homeostasis in insulin-deficient rats. Male Wistar rats were first rendered diabetic th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vitzel, Kaio F., Bikopoulos, George, Hung, Steven, Curi, Rui, Ceddia, Rolando B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743807/ https://www.ncbi.nlm.nih.gov/pubmed/23967267 http://dx.doi.org/10.1371/journal.pone.0071944

Ejemplares similares

Chronic Treatment with the AMP-Kinase Activator AICAR Increases Glycogen Storage and Fatty Acid Oxidation in Skeletal Muscles but Does Not Reduce Hyperglucagonemia and Hyperglycemia in Insulin Deficient Rats
por: Vitzel, Kaio F., et al.
Publicado: (2013)

Enhancement of insulin-mediated rat muscle glucose uptake and microvascular perfusion by 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside
por: Bradley, Eloise A, et al.
Publicado: (2015)

5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Aβ peptide-induced inflammatory mediators in astroglia
por: Ayasolla, Kamesh R, et al.
Publicado: (2005)

Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy
por: Sengupta, Tapas K, et al.
Publicado: (2007)

Cold acclimation reduces hepatic protein Kinase B and AMP‐activated protein kinase phosphorylation and increases gluconeogenesis in Rats
por: Sepa‐Kishi, Diane M., et al.
Publicado: (2018)

Chronic 5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside Treatment Induces Phenotypic Changes in Skeletal Muscle, but Does Not Improve Disease Outcomes in the R6/2 Mouse Model of Huntington’s Disease
por: Paré, Marie-France, et al.
Publicado: (2017)

5-aminoimidazole-4-carboxamide Riboside Induces Apoptosis Through AMP-activated Protein Kinase-independent and NADPH Oxidase-dependent Pathways
por: Wi, Sae Mi, et al.
Publicado: (2014)

Insulin and 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Differentially Regulate the Skeletal Muscle Cell Secretome
por: Gonzalez-Franquesa, Alba, et al.
Publicado: (2021)

Aminoimidazole Carboxamide Ribonucleotide (AICAR) Inhibits the Growth of Retinoblastoma In Vivo by Decreasing Angiogenesis and Inducing Apoptosis
por: Theodoropoulou, Sofia, et al.
Publicado: (2013)

Synthesis and Behavior of DNA Oligomers Containing the Ambiguous Z-Nucleobase 5-Aminoimidazole-4-carboxamide
por: Nogi, Yuhei, et al.
Publicado: (2023)

Fasting differentially alters the hypothalamic proteome of chickens from lines with the propensity to be anorexic or obese
por: Liu, Lingbin, et al.
Publicado: (2019)

Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis
por: Hinks, Anne, et al.
Publicado: (2011)

5-Aminoimidazole-4-carboxamide ribonucleoside-induced autophagy flux during differentiation of monocytic leukemia cells
por: Dembitz, Vilma, et al.
Publicado: (2017)

AMPK Activation by 5-Amino-4-Imidazole Carboxamide Riboside-1-β-D-Ribofuranoside Attenuates Alkali Injury-Induced Corneal Fibrosis
por: Nuwormegbe, Selikem Abla, et al.
Publicado: (2020)

Untargeted metabolomics confirms and extends the understanding of the impact of aminoimidazole carboxamide ribotide (AICAR) in the metabolic network of Salmonella enterica
por: Bazurto, Jannell V., et al.
Publicado: (2017)

5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts
por: Dembitz, Vilma, et al.
Publicado: (2020)

The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN)
por: Gao, Jianlong, et al.
Publicado: (2018)

Influence of Reduced Folate Carrier and Aminoimidazole Carboxamide Ribonucleotide Transformylase gene polymorphisms on the efficacy of methotrexate in juvenile idiopathic arthritis
por: Bilginer, Yelda, et al.
Publicado: (2011)

The effect of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) on fatty acid oxidation in hepatocytes isolated from neonatal piglets
por: Xi, Lin, et al.
Publicado: (2012)

The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting
por: Hall, Derek T, et al.
Publicado: (2018)

Aspirin and 5-Aminoimidazole-4-carboxamide Riboside Attenuate Bovine Ephemeral Fever Virus Replication by Inhibiting BEFV-Induced Autophagy
por: Tseng, Hsu-Hung, et al.
Publicado: (2020)

Cold acclimation causes fiber type-specific responses in glucose and fat metabolism in rat skeletal muscles
por: Sepa-Kishi, Diane M., et al.
Publicado: (2017)

Distinct mechanisms involving diacylglycerol, ceramides, and inflammation underlie insulin resistance in oxidative and glycolytic muscles from high fat-fed rats
por: Jani, Shailee, et al.
Publicado: (2021)

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-Monophosphate (AICAR), a Highly Conserved Purine Intermediate with Multiple Effects
por: Daignan-Fornier, Bertrand, et al.
Publicado: (2012)

The effect of 5-aminoimidazole-4-carboxamide-ribonucleoside was mediated by p38 mitogen activated protein kinase signaling pathway in FRO thyroid cancer cells
por: Kim, Won Gu, et al.
Publicado: (2014)

Solid-Phase Synthesis of a New Diphosphate 5-Aminoimidazole-4-carboxamide Riboside (AICAR) Derivative and Studies toward Cyclic AICAR Diphosphate Ribose
por: D’Errico, Stefano, et al.
Publicado: (2011)

Fasting and postprandial levels of ghrelin, leptin and insulin in lean, obese and anorexic subjects
por: Korek, Emilia, et al.
Publicado: (2013)

Effect of Deer Antler Extract on Muscle Differentiation and 5-Aminoimidazole-4-Carboxamide Ribonucleoside (AICAR)-Induced Muscle Atrophy in C2C12 Cells
por: Jo, Kyungae, et al.
Publicado: (2021)

Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp.
por: Blanco, Cynthia L., et al.
Publicado: (2018)

5-aminoimidazole-4-carboxamide ribonucleotide-transformylase and inosine-triphosphate-pyrophosphatase genes variants predict remission rate during methotrexate therapy in patients with juvenile idiopathic arthritis
por: Pastore, Serena, et al.
Publicado: (2014)

The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax
por: Cosialls, Ana M., et al.
Publicado: (2017)

A discussion of the development of an instrument to measure anorexic symptomatology in men
por: Reeves, Megan
Publicado: (2015)

Gender Difference in Bacteria Endotoxin-Induced Inflammatory and Anorexic Responses
por: Kuo, Shiu-Ming
Publicado: (2016)

Specificity and wealth of autobiographical memories in restrictive and mixed anorexic patients
por: Gandolphe, Marie-Charlotte, et al.
Publicado: (2021)

Optimization of Aminoimidazole Derivatives as Src Family Kinase Inhibitors
por: Francini, Cinzia Maria, et al.
Publicado: (2018)

Hypothalamic AMP-activated Kinase Regulates Glucose-stimulated Insulin Secretion
por: Koh, Eun Hee, et al.
Publicado: (2016)

Characteristic (1)H NMR spectra of β-d-ribofuranosides and ribonucleosides: factors driving furanose ring conformations
por: Walczak, Dominik, et al.
Publicado: (2022)

Chronic stress and adipose tissue in the anorexic state: endocrine and epigenetic mechanisms
por: Xiao, Yang, et al.
Publicado: (2020)

Fuse your mitochondria, lose appetite: an anorexic, anti‐obesity sphingolipid
por: Muley, Carolin, et al.
Publicado: (2021)

Progressive increases in creatine kinase activity in an anorexic cat with necrotising myopathy
por: Chow, Joyce LY, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ar59v815tg3q6ovpnt6p99cue9