Cargando…

Novel Synthetic Monoketone Transmute Radiation-Triggered NFκB-Dependent TNFα Cross-Signaling Feedback Maintained NFκB and Favors Neuroblastoma Regression

Recently, we demonstrated that radiation (IR) instigates the occurrence of a NFκB-TNFα feedback cycle which sustains persistent NFκB activation in neuroblastoma (NB) cells and favors survival advantage and clonal expansion. Further, we reported that curcumin targets IR-induced survival signaling and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aravindan, Sheeja, Natarajan, Mohan, Awasthi, Vibhudutta, Herman, Terence S., Aravindan, Natarajan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743919/ https://www.ncbi.nlm.nih.gov/pubmed/23967300 http://dx.doi.org/10.1371/journal.pone.0072464

Ejemplares similares

Molecular basis of ‘hypoxic’ breast cancer cell radio-sensitization: phytochemicals converge on radiation induced Rel signaling
por: Aravindan, Sheeja, et al.
Publicado: (2013)

Cancer stem cells in neuroblastoma therapy resistance
por: Aravindan, Natarajan, et al.
Publicado: (2019)

MicroRNAs in neuroblastoma tumorigenesis, therapy resistance, and disease evolution
por: Aravindan, Natarajan, et al.
Publicado: (2019)

Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease
por: Ramraj, Satish Kumar, et al.
Publicado: (2016)

Reorganization of metastamiRs in the evolution of metastatic aggressive neuroblastoma cells
por: Khan, Faizan H, et al.
Publicado: (2015)

Acquired genetic alterations in tumor cells dictate the development of high-risk neuroblastoma and clinical outcomes
por: Khan, Faizan H., et al.
Publicado: (2015)

De novo regulation of RD3 synthesis in residual neuroblastoma cells after intensive multi-modal clinical therapy harmonizes disease evolution
por: Somasundaram, Dinesh Babu, et al.
Publicado: (2019)

RD3 loss dictates high-risk aggressive neuroblastoma and poor clinical outcomes
por: Khan, Faizan H., et al.
Publicado: (2015)

Droplet digital PCR as an alternative to FISH for MYCN amplification detection in human neuroblastoma FFPE samples
por: Somasundaram, Dinesh Babu, et al.
Publicado: (2019)

Anti-Pancreatic Cancer Deliverables from Sea: First-Hand Evidence on the Efficacy, Molecular Targets and Mode of Action for Multifarious Polyphenols from Five Different Brown-Algae
por: Aravindan, Sheeja, et al.
Publicado: (2013)

Polyphenols from marine brown algae target radiotherapy-coordinated EMT and stemness-maintenance in residual pancreatic cancer
por: Aravindan, Sheeja, et al.
Publicado: (2015)

High Energy Particle Radiation-associated Oncogenic Transformation in Normal Mice: Insight into the Connection between Activation of Oncotargets and Oncogene Addiction
por: Aravindan, Natarajan, et al.
Publicado: (2016)

Single TNFα trimers mediating NF-κB activation: stochastic robustness of NF-κB signaling
por: Lipniacki, Tomasz, et al.
Publicado: (2007)

Hormophysa triquerta polyphenol, an elixir that deters CXCR4- and COX2-dependent dissemination destiny of treatment-resistant pancreatic cancer cells
por: Aravindan, Sheeja, et al.
Publicado: (2016)

Novel adjuvants from seaweed impede autophagy signaling in therapy-resistant residual pancreatic cancer
por: Aravindan, Sheeja, et al.
Publicado: (2015)

Irreversible EGFR Inhibitor EKB-569 Targets Low-LET γ-Radiation-Triggered Rel Orchestration and Potentiates Cell Death in Squamous Cell Carcinoma
por: Aravindan, Natarajan, et al.
Publicado: (2011)

NF-κB and Disease
por: Poma, Paola
Publicado: (2020)

Several Alphaherpesviruses Interact Similarly with the NF-κB Pathway and Suppress NF-κB-Dependent Gene Expression
por: Romero, Nicolás, et al.
Publicado: (2023)

Expression of the NF-κB inhibitor ABIN-3 in response to TNF and toll-like receptor 4 stimulation is itself regulated by NF-κB
por: Verstrepen, Lynn, et al.
Publicado: (2008)

Mechanism of Probiotic VSL#3 Inhibiting NF-κB and TNF-α on Colitis through TLR4-NF-κB Signal Pathway
por: WANG, Hui, et al.
Publicado: (2019)

NF-κB Members Left Home: NF-κB-Independent Roles in Cancer
por: Colomer, Carlota, et al.
Publicado: (2017)

Retinal Degeneration Protein 3 (RD3) in normal human tissues: Novel insights
por: Aravindan, Sheeja, et al.
Publicado: (2017)

NF-κB and the Immunoglobulin κ Gene Enhancer
por: Sen, Ranjan
Publicado: (2004)

Analysis of variation in NF-κB genes and expression levels of NF-κB-regulated molecules
por: Liu-Mares, Wen, et al.
Publicado: (2007)

Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function
por: Gao, Huanqing, et al.
Publicado: (2023)

TNF activation of NF-κB is essential for development of single-positive thymocytes
por: Webb, Louise V., et al.
Publicado: (2016)

NF-κB fingerprinting reveals heterogeneous NF-κB composition in diffuse large B-cell lymphoma
por: Jayawant, Eleanor, et al.
Publicado: (2023)

Keeping NF-κB in check
por: Williams, Ruth
Publicado: (2006)

At the crossroads of SUMO and NF-κB
por: Kracklauer, Martin P, et al.
Publicado: (2003)

Slow but steady for NF-κB
por: Leslie, Mitch
Publicado: (2012)

NF-κB in premature aging
por: Osorio, Fernando G., et al.
Publicado: (2012)

Hypoxia Induced NF-κB
por: D’Ignazio, Laura, et al.
Publicado: (2016)

NF-κB signaling in inflammation
por: Liu, Ting, et al.
Publicado: (2017)

Noncanonical NF-κB in Cancer
por: Tegowski, Matthew, et al.
Publicado: (2018)

NFκB and Kidney Injury
por: Song, Ning, et al.
Publicado: (2019)

NF-κB in Hematological Malignancies
por: Imbert, Véronique, et al.
Publicado: (2017)

NF-κB Signalling in Glioblastoma
por: Soubannier, Vincent, et al.
Publicado: (2017)

N-Myc-Interacting Protein Negatively Regulates TNF-α-Induced NF-κB Transcriptional Activity by Sequestering NF-κB/p65 in the Cytoplasm
por: Hou, Jingjing, et al.
Publicado: (2017)

To NFκB or not to NFκB: The Dilemma on How to Inhibit a Cancer Cell Fate Regulator
por: Sorriento, Daniela, et al.
Publicado: (2012)

Non-canonical NFκB mutations reinforce pro-survival TNF response in multiple myeloma through an autoregulatory RelB:p50 NFκB pathway
por: Roy, P, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_db8ruopbl7rpe8qpnacmk1fmq7