Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

Transcription factor Nrf2 and its repressor Keap1 regulate a network of cytoprotective genes involving more than 1% of the genome, their best known targets being drug-metabolizing and antioxidant genes. Here we demonstrate a novel role for this pathway in directly regulating mitochondrial bioenerget...

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Detalles Bibliográficos
Autores principales: Holmström, Kira M., Baird, Liam, Zhang, Ying, Hargreaves, Iain, Chalasani, Annapurna, Land, John M., Stanyer, Lee, Yamamoto, Masayuki, Dinkova-Kostova, Albena T., Abramov, Andrey Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744067/
https://www.ncbi.nlm.nih.gov/pubmed/23951401
http://dx.doi.org/10.1242/bio.20134853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744067/
https://www.ncbi.nlm.nih.gov/pubmed/23951401
http://dx.doi.org/10.1242/bio.20134853

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