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The Hippo pathway acts via p53 and microRNAs to control proliferation and proapoptotic gene expression during tissue growth
The Hippo pathway has a central role in coordinating tissue growth and apoptosis. Mutations that compromise Hippo pathway activity cause tissue overgrowth and have been causally linked to cancer. In Drosophila, the transcriptional coactivator Yorkie mediates Hippo pathway activity to control the exp...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744074/ https://www.ncbi.nlm.nih.gov/pubmed/23951408 http://dx.doi.org/10.1242/bio.20134317 |