Biochemical Competition Makes Fatty-Acid β-Oxidation Vulnerable to Substrate Overload

Fatty-acid metabolism plays a key role in acquired and inborn metabolic diseases. To obtain insight into the network dynamics of fatty-acid β-oxidation, we constructed a detailed computational model of the pathway and subjected it to a fat overload condition. The model contains reversible and satura...

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Detalles Bibliográficos
Autores principales: van Eunen, Karen, Simons, Sereh M. J., Gerding, Albert, Bleeker, Aycha, den Besten, Gijs, Touw, Catharina M. L., Houten, Sander M., Groen, Bert K., Krab, Klaas, Reijngoud, Dirk-Jan, Bakker, Barbara M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744394/
https://www.ncbi.nlm.nih.gov/pubmed/23966849
http://dx.doi.org/10.1371/journal.pcbi.1003186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744394/
https://www.ncbi.nlm.nih.gov/pubmed/23966849
http://dx.doi.org/10.1371/journal.pcbi.1003186

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