Characterization of the p53 Cistrome – DNA Binding Cooperativity Dissects p53's Tumor Suppressor Functions

p53 protects us from cancer by transcriptionally regulating tumor suppressive programs designed to either prevent the development or clonal expansion of malignant cells. How p53 selects target genes in the genome in a context- and tissue-specific manner remains largely obscure. There is growing evid...

Descripción completa

Detalles Bibliográficos
Autores principales: Schlereth, Katharina, Heyl, Charlotte, Krampitz, Anna-Maria, Mernberger, Marco, Finkernagel, Florian, Scharfe, Maren, Jarek, Michael, Leich, Ellen, Rosenwald, Andreas, Stiewe, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744428/
https://www.ncbi.nlm.nih.gov/pubmed/23966881
http://dx.doi.org/10.1371/journal.pgen.1003726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744428/
https://www.ncbi.nlm.nih.gov/pubmed/23966881
http://dx.doi.org/10.1371/journal.pgen.1003726

Ejemplares similares