Coronaviruses Lacking Exoribonuclease Activity Are Susceptible to Lethal Mutagenesis: Evidence for Proofreading and Potential Therapeutics

No therapeutics or vaccines currently exist for human coronaviruses (HCoVs). The Severe Acute Respiratory Syndrome-associated coronavirus (SARS-CoV) epidemic in 2002–2003, and the recent emergence of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in April 2012, emphasize the high probabilit...

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Detalles Bibliográficos
Autores principales: Smith, Everett Clinton, Blanc, Hervé, Vignuzzi, Marco, Denison, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744431/
https://www.ncbi.nlm.nih.gov/pubmed/23966862
http://dx.doi.org/10.1371/journal.ppat.1003565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744431/
https://www.ncbi.nlm.nih.gov/pubmed/23966862
http://dx.doi.org/10.1371/journal.ppat.1003565

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