Genomic Deregulation of the E2F/Rb Pathway Leads to Activation of the Oncogene EZH2 in Small Cell Lung Cancer

Small cell lung cancer (SCLC) is a highly aggressive lung neoplasm with extremely poor clinical outcomes and no approved targeted treatments. To elucidate the mechanisms responsible for driving the SCLC phenotype in hopes of revealing novel therapeutic targets, we studied copy number and methylation...

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Detalles Bibliográficos
Autores principales: Coe, Bradley P., Thu, Kelsie L., Aviel-Ronen, Sarit, Vucic, Emily A., Gazdar, Adi F., Lam, Stephen, Tsao, Ming-Sound, Lam, Wan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744458/
https://www.ncbi.nlm.nih.gov/pubmed/23967231
http://dx.doi.org/10.1371/journal.pone.0071670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744458/
https://www.ncbi.nlm.nih.gov/pubmed/23967231
http://dx.doi.org/10.1371/journal.pone.0071670

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