Cargando…

PKC Activation in Niemann Pick C1 Cells Restores Subcellular Cholesterol Transport

Activation of protein kinase C (PKC) has previously been shown to ameliorate the cholesterol transport defect in Niemann Pick Type C1 (NPC1) cells, presumably by increasing the soluble levels of one of its substrates, vimentin. This activity would then restore the vimentin cycle in these cells and a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tamari, Farshad, Chen, Fannie W., Li, Chunlei, Chaudhari, Jagrutiben, Ioannou, Yiannis A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744505/ https://www.ncbi.nlm.nih.gov/pubmed/23977398 http://dx.doi.org/10.1371/journal.pone.0074169

Ejemplares similares

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1
por: Carette, Jan E., et al.
Publicado: (2011)

Baculovirus Utilizes Cholesterol Transporter NIEMANN–Pick C1 for Host Cell Entry
por: Li, Zhihong, et al.
Publicado: (2019)

Mitochondrial Cholesterol in Alzheimer's Disease and Niemann–Pick Type C Disease
por: Torres, Sandra, et al.
Publicado: (2019)

The intracellular transport of low density lipoprotein-derived cholesterol is defective in Niemann-Pick type C fibroblasts
Publicado: (1989)

Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1
por: Trinh, Michael Nguyen, et al.
Publicado: (2018)

Niemann-Pick disease type C
por: Vanier, Marie T
Publicado: (2010)

Activation Mobilizes the Cholesterol in the Late Endosomes-Lysosomes of Niemann Pick Type C Cells
por: Lange, Yvonne, et al.
Publicado: (2012)

Rapid Diagnosis of 83 Patients with Niemann Pick Type C Disease and Related Cholesterol Transport Disorders by Cholestantriol Screening()
por: Reunert, Janine, et al.
Publicado: (2015)

Lysosomal-specific Cholesterol Reduction by Biocleavable Polyrotaxanes for Ameliorating Niemann-Pick Type C Disease
por: Tamura, Atsushi, et al.
Publicado: (2014)

Laboratory diagnosis of the Niemann-Pick type C disease: an inherited neurodegenerative disorder of cholesterol metabolism
por: Sitarska, Dominika, et al.
Publicado: (2019)

Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation
por: Dominko, Kristina, et al.
Publicado: (2021)

Inhibitory Effect of Isoliquiritigenin in Niemann-Pick C1-Like 1-Mediated Cholesterol Uptake
por: Zeng, Jun, et al.
Publicado: (2022)

Different solubilizing ability of cyclodextrin derivatives for cholesterol in Niemann–Pick disease type C treatment
por: Yamada, Yusei, et al.
Publicado: (2023)

Luteolin and Quercetin Affect the Cholesterol Absorption Mediated by Epithelial Cholesterol Transporter Niemann–Pick C1-Like 1 in Caco-2 Cells and Rats
por: Nekohashi, Mari, et al.
Publicado: (2014)

Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells
por: Ebrahimi-Fakhari, Darius, et al.
Publicado: (2016)

A therapy with miglustat, 2-hydroxypropyl-ß-cyclodextrin and allopregnanolone restores splenic cholesterol homeostasis in Niemann-pick disease type C1
por: Neßlauer, Anna-Maria, et al.
Publicado: (2019)

The prognostic value of Niemann-Pick C1-like protein 1 and Niemann-Pick disease type C2 in hepatocellular carcinoma
por: Chen, Ke-Ji, et al.
Publicado: (2018)

Impact of Organelle Transport Deficits on Mitophagy and Autophagy in Niemann–Pick Disease Type C
por: Liedtke, Maik, et al.
Publicado: (2022)

Visualization of cholesterol deposits in lysosomes of Niemann-Pick type C fibroblasts using recombinant perfringolysin O
por: Kwiatkowska, Katarzyna, et al.
Publicado: (2014)

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection
por: Gong, Xin, et al.
Publicado: (2016)

HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts
por: Pipalia, Nina H., et al.
Publicado: (2021)

Immune dysfunction in Niemann‐Pick disease type C
por: Platt, Nick, et al.
Publicado: (2015)

A calcium message for Niemann-Pick type C
por: Cologna, Stephanie M.
Publicado: (2019)

Treatment trials in Niemann-Pick type C disease
por: Sitarska, Dominika, et al.
Publicado: (2021)

Iron Limitation Restores Autophagy and Increases Lifespan in the Yeast Model of Niemann–Pick Type C1
por: Martins, Telma S., et al.
Publicado: (2023)

Clinical disease characteristics of patients with Niemann-Pick Disease Type C: findings from the International Niemann-Pick Disease Registry (INPDR)
por: Bolton, Shaun C., et al.
Publicado: (2022)

Stem Cells and Niemann Pick Disease
por: Andolina, Marino
Publicado: (2014)

Stem Cells in Niemann-Pick Disease
por: Kim, Sun-Jung, et al.
Publicado: (2008)

Niemann-Pick disease and platelet dysfunction
Publicado: (2012)

Cholesterol Pathways Affected by Small Molecules That Decrease Sterol Levels in Niemann-Pick Type C Mutant Cells
por: Rujoi, Madalina, et al.
Publicado: (2010)

Quantitative Comparison of the Efficacy of Various Compounds in Lowering Intracellular Cholesterol Levels in Niemann-Pick Type C Fibroblasts
por: Wehrmann, Zachary T., et al.
Publicado: (2012)

Drug‐induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann–Pick type C cells and mice
por: Moreau, Dimitri, et al.
Publicado: (2019)

Intestinal and Hepatic Niemann-Pick C1-Like 1
por: Park, Sung-Woo
Publicado: (2013)

Niemann Pick C disease: lessons from zebrafish development
Publicado: (2011)

Complement is dispensable for neurodegeneration in Niemann-Pick disease type C
por: Lopez, Manuel E, et al.
Publicado: (2012)

Efficacy and ototoxicity of different cyclodextrins in Niemann–Pick C disease
por: Davidson, Cristin D., et al.
Publicado: (2016)

Genome sequencing in a case of Niemann–Pick type C
por: Dougherty, Max, et al.
Publicado: (2016)

Retinal axonal degeneration in Niemann–Pick type C disease
por: Havla, Joachim, et al.
Publicado: (2020)

Estimated prevalence of Niemann–Pick type C disease in Quebec
por: Labrecque, Marjorie, et al.
Publicado: (2021)

Spectrum of Movement Disorders in Niemann-Pick Disease Type C
por: Devaraj, Rashmi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_nrtulp37cii46khkbp56qn4fkl