Cargando…

Cognitive Dysfunction Precedes the Onset of Motor Symptoms in the MitoPark Mouse Model of Parkinson’s Disease

Parkinson’s disease (PD) is a neurodegenerative disorder primarily characterized by progressive loss of dopamine neurons, leading to loss of motor coordination. However, PD is associated with a high rate of non-motor neuropsychiatric comorbities that often develop before the onset of movement sympto...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xiuhua, Redus, Laney, Chen, Cang, Martinez, Paul A., Strong, Randy, Li, Senlin, O’Connor, Jason C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744561/ https://www.ncbi.nlm.nih.gov/pubmed/23977020 http://dx.doi.org/10.1371/journal.pone.0071341

Ejemplares similares

Multimodal MRI Evaluation of the MitoPark Mouse Model of Parkinson’s Disease
por: Cong, Linlin, et al.
Publicado: (2016)

GDNF-expressing macrophages mitigate loss of dopamine neurons and improve Parkinsonian symptoms in MitoPark mice
por: Chen, Cang, et al.
Publicado: (2018)

Mechanisms of Sleep/Wake Regulation under Hypodopaminergic State: Insights from MitoPark Mouse Model of Parkinson's Disease
por: Fifel, Karim, et al.
Publicado: (2022)

Chronic L-DOPA induces hyperactivity, normalization of gait and dyskinetic behavior in MitoPark mice
por: Gellhaar, S, et al.
Publicado: (2015)

Chronic L‐DOPA induces hyperactivity, normalization of gait and dyskinetic behavior in MitoPark mice
Publicado: (2015)

PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice
por: Zhang, YaJun, et al.
Publicado: (2012)

Kynurenine metabolic balance is disrupted in the hippocampus following peripheral lipopolysaccharide challenge
por: Parrott, Jennifer M., et al.
Publicado: (2016)

Low-Level Stress Induces Production of Neuroprotective Factors in Wild-Type but Not BDNF(+/-) Mice: Interleukin-10 and Kynurenic Acid
por: Dugan, Allison M., et al.
Publicado: (2015)

The Bologna motor and non-motor prospective study on parkinsonism at onset (BoProPark): study design and population
por: Calandra-Buonaura, Giovanna, et al.
Publicado: (2020)

Leg restlessness preceding the onset of motor symptoms of Parkinson disease: A case series of 5 patients
por: Suzuki, Keisuke, et al.
Publicado: (2019)

Tryptophan Metabolism in Patients With Chronic Kidney Disease Secondary to Type 2 Diabetes: Relationship to Inflammatory Markers
por: Debnath, Subrata, et al.
Publicado: (2017)

Neurodegeneration and Motor Dysfunction in Mice Lacking Cytosolic and Mitochondrial Aldehyde Dehydrogenases: Implications for Parkinson's Disease
por: Wey, Margaret Chia-Ying, et al.
Publicado: (2012)

Non-toxic HSC Transplantation-Based Macrophage/Microglia-Mediated GDNF Delivery for Parkinson’s Disease
por: Chen, Cang, et al.
Publicado: (2019)

Parkinson’s disease GWAS-linked Park16 carriers show greater motor progression
por: Deng, Xiao, et al.
Publicado: (2019)

Parkin (PARK 2) Mutations Are Rare in Czech Patients with Early-Onset Parkinson's Disease
por: Fiala, Ondrej, et al.
Publicado: (2014)

Identification of Characteristic Motor Patterns Preceding Freezing of Gait in Parkinson’s Disease Using Wearable Sensors
por: Palmerini, Luca, et al.
Publicado: (2017)

Compound heterozygous mutations in PARK2 causing early-onset Parkinson disease: A case report
por: Fang, Yu-Qing, et al.
Publicado: (2019)

Axonal Dysfunction Precedes Motor Neuronal Death in Amyotrophic Lateral Sclerosis
por: Iwai, Yuta, et al.
Publicado: (2016)

A Novel Mutation of PARK-2 Gene in a Patient with Early-onset Parkinson’s Disease
por: Alafifi, Tariq, et al.
Publicado: (2020)

Quantitative Assessment of Motor Response to a Low Subacute Levodopa Dose in the Differential Diagnosis of Parkinsonisms at Disease Onset: Data from the BoProPark Cohort
por: Contin, Manuela, et al.
Publicado: (2021)

Sexual dysfunction precedes motor defects, dopaminergic neuronal degeneration, and impaired dopamine metabolism: Insights from Drosophila model of Parkinson’s disease
por: Koza, Zevelou, et al.
Publicado: (2023)

Neurochemical and motor changes in mice with combined mutations linked to Parkinson’s disease
por: Bai, Xiang, et al.
Publicado: (2017)

Herpetic Keratitis Preceded by COVID-19 Vaccination
por: Li, Saiqun, et al.
Publicado: (2021)

Charting the onset of Parkinson-like motor and non-motor symptoms in nonhuman primate model of Parkinson’s disease
por: Choudhury, Gourav R., et al.
Publicado: (2018)

Mitochondrial dysfunction in Parkinson disease: evidence in mutant PARK2 fibroblasts
por: Zanellati, Maria C., et al.
Publicado: (2015)

Respiratory Infections Precede Adult-Onset Asthma
por: Rantala, Aino, et al.
Publicado: (2011)

Genetic Analysis of PARK2 and PINK1 Genes in Brazilian Patients with Early-Onset Parkinson's Disease
por: Moura, Karla Cristina Vasconcelos, et al.
Publicado: (2013)

Analysis of Dosage Mutation in PARK2 among Korean Patients with Early-Onset or Familial Parkinson's Disease
por: Chu, Min Kyung, et al.
Publicado: (2014)

PARK7-Related Early Onset Parkinson Disease in the Setting of Complete Uniparental Isodisomy of Chromosome 1
por: Xiao, Changrui, et al.
Publicado: (2021)

Novel compound heterozygous mutations in the PARK2 gene identified in a Chinese pedigree with early‐onset Parkinson's disease
por: Shi, Yingying, et al.
Publicado: (2017)

PARK Genes Link Mitochondrial Dysfunction and Alpha-Synuclein Pathology in Sporadic Parkinson’s Disease
por: Li, Wen, et al.
Publicado: (2021)

Spatial changes in park visitation at the onset of the pandemic
por: Linnell, Kelsey, et al.
Publicado: (2022)

Erratum: Analysis of Dosage Mutation in PARK2 among Korean Patients with Early-Onset or Familial Parkinson's Disease
por: Chu, Min Kyung, et al.
Publicado: (2015)

Pregnancy in Parkinson's disease with PARK2 mutations()()
por: Sazci, Ali, et al.
Publicado: (2019)

Corneal dysfunction precedes the onset of hyperglycemia in a mouse model of diet-induced obesity
por: Hargrave, Aubrey, et al.
Publicado: (2020)

The Onset of Eosinophilic Pneumonia Preceding Anti-synthetase Syndrome
por: Hachisu, Yoshimasa, et al.
Publicado: (2017)

Altered hippocampal interneuron activity precedes ictal onset
por: Miri, Mitra L, et al.
Publicado: (2018)

Epigenetic Changes in Islets of Langerhans Preceding the Onset of Diabetes
por: Ouni, Meriem, et al.
Publicado: (2020)

Progressive Motor and Non-Motor Symptoms in Park7 Knockout Zebrafish
por: Chavali, Lakshmi Narasimha Murthy, et al.
Publicado: (2023)

Decreased complexity of glucose dynamics preceding the onset of diabetes in mice and rats
por: Zhang, Xiaohua Douglas, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_jsuutubb59f6sgfnm5095lh884