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Probiotic Beverage with Soy Isoflavone Consumption for Breast Cancer Prevention: A Case-control Study

The purpose of this study is to evaluate how beverages containing Lactobacillus casei Shirota (BLS) and soy isoflavone consumption since adolescence affected the incidence of breast cancer. In a population-based case-control study, three hundred and six cases with breast cancer and 662 controls aged...

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Autores principales: Toi, Masakazu, Hirota, Saya, Tomotaki, Ai, Sato, Nobuaki, Hozumi, Yasuo, Anan, Keisei, Nagashima, Takeshi, Tokuda, Yutaka, Masuda, Norikazu, Ohsumi, Shozo, Ohno, Shinji, Takahashi, Masato, Hayashi, Hironori, Yamamoto, Seiichiro, Ohashi, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744907/
https://www.ncbi.nlm.nih.gov/pubmed/23966890
http://dx.doi.org/10.2174/15734013113099990001
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author Toi, Masakazu
Hirota, Saya
Tomotaki, Ai
Sato, Nobuaki
Hozumi, Yasuo
Anan, Keisei
Nagashima, Takeshi
Tokuda, Yutaka
Masuda, Norikazu
Ohsumi, Shozo
Ohno, Shinji
Takahashi, Masato
Hayashi, Hironori
Yamamoto, Seiichiro
Ohashi, Yasuo
author_facet Toi, Masakazu
Hirota, Saya
Tomotaki, Ai
Sato, Nobuaki
Hozumi, Yasuo
Anan, Keisei
Nagashima, Takeshi
Tokuda, Yutaka
Masuda, Norikazu
Ohsumi, Shozo
Ohno, Shinji
Takahashi, Masato
Hayashi, Hironori
Yamamoto, Seiichiro
Ohashi, Yasuo
author_sort Toi, Masakazu
collection PubMed
description The purpose of this study is to evaluate how beverages containing Lactobacillus casei Shirota (BLS) and soy isoflavone consumption since adolescence affected the incidence of breast cancer. In a population-based case-control study, three hundred and six cases with breast cancer and 662 controls aged 40 to 55 were matched for age and residential area and included in the analyses. Diet, lifestyle and other breast cancer risk factors were investigated using the self-administered questionnaire and interview. Odds ratios (ORs) of BLS and soy isoflavone consumption for breast cancer incidence were independently and jointly estimated using a conditional logistic regression. The ORs of BLS consumption (≥ four times a week against < four times a week) was 0.65 and statistically significant (p = 0.048). The analysis of association between soy consumption and breast cancer incidence showed the more the isoflavone consumption is, the lower the odds of breast cancer becomes. Adjusted ORs for breast cancer in the second, the third and the fourth quartiles of soy consumption against the first quartile were 0.76, 0.53 and 0.48, respectively (trend test, p = 0.0002). The BLS-isoflavone interaction was not statistically significant; however, a biological interaction was suggested. Regular consumption of BLS and isoflavones since adolescence was inversely associated with the incidence of breast cancer in Japanese women.
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spelling pubmed-37449072013-08-19 Probiotic Beverage with Soy Isoflavone Consumption for Breast Cancer Prevention: A Case-control Study Toi, Masakazu Hirota, Saya Tomotaki, Ai Sato, Nobuaki Hozumi, Yasuo Anan, Keisei Nagashima, Takeshi Tokuda, Yutaka Masuda, Norikazu Ohsumi, Shozo Ohno, Shinji Takahashi, Masato Hayashi, Hironori Yamamoto, Seiichiro Ohashi, Yasuo Curr Nutr Food Sci Article The purpose of this study is to evaluate how beverages containing Lactobacillus casei Shirota (BLS) and soy isoflavone consumption since adolescence affected the incidence of breast cancer. In a population-based case-control study, three hundred and six cases with breast cancer and 662 controls aged 40 to 55 were matched for age and residential area and included in the analyses. Diet, lifestyle and other breast cancer risk factors were investigated using the self-administered questionnaire and interview. Odds ratios (ORs) of BLS and soy isoflavone consumption for breast cancer incidence were independently and jointly estimated using a conditional logistic regression. The ORs of BLS consumption (≥ four times a week against < four times a week) was 0.65 and statistically significant (p = 0.048). The analysis of association between soy consumption and breast cancer incidence showed the more the isoflavone consumption is, the lower the odds of breast cancer becomes. Adjusted ORs for breast cancer in the second, the third and the fourth quartiles of soy consumption against the first quartile were 0.76, 0.53 and 0.48, respectively (trend test, p = 0.0002). The BLS-isoflavone interaction was not statistically significant; however, a biological interaction was suggested. Regular consumption of BLS and isoflavones since adolescence was inversely associated with the incidence of breast cancer in Japanese women. Bentham Science Publishers 2013-08 2013-08 /pmc/articles/PMC3744907/ /pubmed/23966890 http://dx.doi.org/10.2174/15734013113099990001 Text en © Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Toi, Masakazu
Hirota, Saya
Tomotaki, Ai
Sato, Nobuaki
Hozumi, Yasuo
Anan, Keisei
Nagashima, Takeshi
Tokuda, Yutaka
Masuda, Norikazu
Ohsumi, Shozo
Ohno, Shinji
Takahashi, Masato
Hayashi, Hironori
Yamamoto, Seiichiro
Ohashi, Yasuo
Probiotic Beverage with Soy Isoflavone Consumption for Breast Cancer Prevention: A Case-control Study
title Probiotic Beverage with Soy Isoflavone Consumption for Breast Cancer Prevention: A Case-control Study
title_full Probiotic Beverage with Soy Isoflavone Consumption for Breast Cancer Prevention: A Case-control Study
title_fullStr Probiotic Beverage with Soy Isoflavone Consumption for Breast Cancer Prevention: A Case-control Study
title_full_unstemmed Probiotic Beverage with Soy Isoflavone Consumption for Breast Cancer Prevention: A Case-control Study
title_short Probiotic Beverage with Soy Isoflavone Consumption for Breast Cancer Prevention: A Case-control Study
title_sort probiotic beverage with soy isoflavone consumption for breast cancer prevention: a case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744907/
https://www.ncbi.nlm.nih.gov/pubmed/23966890
http://dx.doi.org/10.2174/15734013113099990001
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