Novel Multiplexed Assay for Identifying SH2 Domain Antagonists of STAT Family Proteins

Some of the signal transducer and activator of transcription (STAT) family members are constitutively activated in a wide variety of human tumors. The activity of STAT depends on their Src homology 2 (SH2) domain-mediated binding to sequences containing phosphorylated tyrosine. Thus, antagonizing th...

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Detalles Bibliográficos
Autores principales: Takakuma, Kazuyuki, Ogo, Naohisa, Uehara, Yutaka, Takahashi, Susumu, Miyoshi, Nao, Asai, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745430/
https://www.ncbi.nlm.nih.gov/pubmed/23977103
http://dx.doi.org/10.1371/journal.pone.0071646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745430/
https://www.ncbi.nlm.nih.gov/pubmed/23977103
http://dx.doi.org/10.1371/journal.pone.0071646

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