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Novel Multiplexed Assay for Identifying SH2 Domain Antagonists of STAT Family Proteins
Some of the signal transducer and activator of transcription (STAT) family members are constitutively activated in a wide variety of human tumors. The activity of STAT depends on their Src homology 2 (SH2) domain-mediated binding to sequences containing phosphorylated tyrosine. Thus, antagonizing th...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745430/ https://www.ncbi.nlm.nih.gov/pubmed/23977103 http://dx.doi.org/10.1371/journal.pone.0071646 |