The Toll-Like Receptor Agonist Imiquimod Is Active against Prions

Using a yeast-based assay, a previously unsuspected antiprion activity was found for imiquimod (IQ), a potent Toll-like receptor 7 (TLR7) agonist already used for clinical applications. The antiprion activity of IQ was first detected against yeast prions [PSI (+)] and [URE3], and then against mammal...

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Detalles Bibliográficos
Autores principales: Oumata, Nassima, Nguyen, Phu hai, Beringue, Vincent, Soubigou, Flavie, Pang, Yanhong, Desban, Nathalie, Massacrier, Catherine, Morel, Yannis, Paturel, Carine, Contesse, Marie-Astrid, Bouaziz, Serge, Sanyal, Suparna, Galons, Hervé, Blondel, Marc, Voisset, Cécile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745460/
https://www.ncbi.nlm.nih.gov/pubmed/23977222
http://dx.doi.org/10.1371/journal.pone.0072112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745460/
https://www.ncbi.nlm.nih.gov/pubmed/23977222
http://dx.doi.org/10.1371/journal.pone.0072112

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