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Transport Inhibition of Digoxin Using Several Common P-gp Expressing Cell Lines Is Not Necessarily Reporting Only on Inhibitor Binding to P-gp

We have reported that the P-gp substrate digoxin required basolateral and apical uptake transport in excess of that allowed by digoxin passive permeability (as measured in the presence of GF120918) to achieve the observed efflux kinetics across MDCK-MDR1-NKI (The Netherlands Cancer Institute) conflu...

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Detalles Bibliográficos
Autores principales: Lumen, Annie Albin, Li, Libin, Li, Jiben, Ahmed, Zeba, Meng, Zhou, Owen, Albert, Ellens, Harma, Hidalgo, Ismael J., Bentz, Joe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745465/
https://www.ncbi.nlm.nih.gov/pubmed/23976943
http://dx.doi.org/10.1371/journal.pone.0069394