Cargando…

Rotenone Upregulates Alpha-Synuclein and Myocyte Enhancer Factor 2D Independently from Lysosomal Degradation Inhibition

Dysfunctions of chaperone-mediated autophagy (CMA), the main catabolic pathway for alpha-synuclein, have been linked to the pathogenesis of Parkinson's disease (PD). Since till now there is limited information on how PD-related toxins may affect CMA, in this study we explored the effect of mito...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sala, Gessica, Arosio, Alessandro, Stefanoni, Giovanni, Melchionda, Laura, Riva, Chiara, Marinig, Daniele, Brighina, Laura, Ferrarese, Carlo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745903/ https://www.ncbi.nlm.nih.gov/pubmed/23984410 http://dx.doi.org/10.1155/2013/846725

Ejemplares similares

Role of Chaperone-Mediated Autophagy Dysfunctions in the Pathogenesis of Parkinson’s Disease
por: Sala, Gessica, et al.
Publicado: (2016)

Direct current stimulation enhances neuronal alpha-synuclein degradation in vitro
por: Sala, Gessica, et al.
Publicado: (2021)

Author Correction: Direct current stimulation enhances neuronal alpha-synuclein degradation in vitro
por: Sala, Gessica, et al.
Publicado: (2021)

Saposin C, Key Regulator in the Alpha-Synuclein Degradation Mediated by Lysosome
por: Ruz, Clara, et al.
Publicado: (2022)

Biophysical Characterization of α-Synuclein and Rotenone Interaction
por: Silva, Blanca A., et al.
Publicado: (2013)

Cerebrospinal Fluid Lysosomal Enzymes and Alpha-Synuclein in Parkinson's Disease
por: Parnetti, Lucilla, et al.
Publicado: (2014)

Riluzole Selective Antioxidant Effects in Cell Models Expressing Amyotrophic Lateral Sclerosis Endophenotypes
por: Sala, Gessica, et al.
Publicado: (2019)

Ndfip1 Prevents Rotenone-Induced Neurotoxicity and Upregulation of α-Synuclein in SH-SY5Y Cells
por: Liu, Xin, et al.
Publicado: (2021)

Changes of lysosome by L-serine in rotenone-treated hippocampal neurons
por: Shin, Sumin, et al.
Publicado: (2023)

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
por: Alvarez-Erviti, Lydia, et al.
Publicado: (2011)

Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models
por: Drobny, Alice, et al.
Publicado: (2023)

Lysosomal lipid alterations caused by glucocerebrosidase deficiency promote lysosomal dysfunction, chaperone-mediated-autophagy deficiency, and alpha-synuclein pathology
por: Navarro-Romero, Alba, et al.
Publicado: (2022)

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
por: Qiao, Liyan, et al.
Publicado: (2008)

Current Evidence for a Bidirectional Loop Between the Lysosome and Alpha-Synuclein Proteoforms
por: Wildburger, Norelle C., et al.
Publicado: (2020)

Histone Deacetylase 4 Inhibition Reduces Rotenone-Induced Alpha-Synuclein Accumulation via Autophagy in SH-SY5Y Cells
por: Wang, Luxi, et al.
Publicado: (2023)

The Overcrowded Crossroads: Mitochondria, Alpha-Synuclein, and the Endo-Lysosomal System Interaction in Parkinson’s Disease
por: Lin, Kai-Jung, et al.
Publicado: (2019)

Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion
por: Tang, Qilin, et al.
Publicado: (2021)

Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity
por: Yu, Meigen, et al.
Publicado: (2023)

Therapeutic Effects of Conditioned Medium of Neural Differentiated Human Bone Marrow-Derived Stem Cells on Rotenone-Induced Alpha-Synuclein Aggregation and Apoptosis
por: Ramalingam, Mahesh, et al.
Publicado: (2021)

Alteration of Dynein Function Affects α-Synuclein Degradation via the Autophagosome-Lysosome Pathway
por: Li, Da, et al.
Publicado: (2013)

Direct Visualization of CHIP-Mediated Degradation of Alpha-Synuclein In Vivo: Implications for PD Therapeutics
por: Dimant, Hemi, et al.
Publicado: (2014)

Phytochemicals Bridging Autophagy Induction and Alpha-Synuclein Degradation in Parkinsonism
por: Limanaqi, Fiona, et al.
Publicado: (2019)

Rotenone Blocks the Glucocerebrosidase Enzyme and Induces the Accumulation of Lysosomes and Autophagolysosomes Independently of LRRK2 Kinase in HEK-293 Cells
por: Perez-Abshana, Laura Patricia, et al.
Publicado: (2023)

Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum
por: Miraglia, Fabiana, et al.
Publicado: (2020)

Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis
por: Freeman, David, et al.
Publicado: (2013)

Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose
por: Hoffmann, Anna-Carin, et al.
Publicado: (2019)

The Convergence of Alpha-Synuclein, Mitochondrial, and Lysosomal Pathways in Vulnerability of Midbrain Dopaminergic Neurons in Parkinson’s Disease
por: Minakaki, Georgia, et al.
Publicado: (2020)

Protein aggregation containing beta-amyloid, alpha-synuclein and hyperphosphorylated tau in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure
por: Chaves, Rodrigo S, et al.
Publicado: (2010)

Analysis of vesicular monoamine transporter 2 polymorphisms in Parkinson’s disease
por: Brighina, Laura, et al.
Publicado: (2013)

Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes
por: Scheiblich, Hannah, et al.
Publicado: (2021)

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein
por: Dening, Yanina, et al.
Publicado: (2022)

Loss of β-Glucocerebrosidase Activity Does Not Affect Alpha-Synuclein Levels or Lysosomal Function in Neuronal Cells
por: Dermentzaki, Georgia, et al.
Publicado: (2013)

Aggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to Lysosomes
por: Domert, Jakob, et al.
Publicado: (2016)

Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s Disease
por: Sepúlveda, Denisse, et al.
Publicado: (2022)

SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine
por: Zhu, Lin-nan, et al.
Publicado: (2018)

Live cell in situ lysosomal GCase activity correlates to alpha-synuclein levels in human differentiated neurons with LRRK2 and GBA1 mutations
por: Labrador-Garrido, Adahir, et al.
Publicado: (2023)

Correction: Loss of β-Glucocerebrosidase Activity Does Not Affect Alpha-Synuclein Levels or Lysosomal Function in Neuronal Cells
por: Dermentzaki, Georgia, et al.
Publicado: (2021)

Hepcidin Decreases Rotenone-Induced α-Synuclein Accumulation via Autophagy in SH-SY5Y Cells
por: Li, Meiqi, et al.
Publicado: (2020)

Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia
por: Bao, Jintao, et al.
Publicado: (2016)

Autophagy–lysosome pathway alterations and alpha-synuclein up-regulation in the subtype of neuronal ceroid lipofuscinosis, CLN5 disease
por: Adams, Jessie, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_vj7h4i42mp7q1ev6a71a3uc4jj