High Glucose-Induced Oxidative Stress Increases the Copy Number of Mitochondrial DNA in Human Mesangial Cells

Oxidative damage to mitochondrial DNA (mtDNA) has been linked to the pathogenicity of diabetic nephropathy. We tested the hypothesis that mtDNA copy number may be increased in human mesangial cells in response to high glucose-induced reactive oxygen species (ROS) to compensate for damaged mtDNA. The...

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Detalles Bibliográficos
Autores principales: Al-Kafaji, Ghada, Golbahar, Jamal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745925/
https://www.ncbi.nlm.nih.gov/pubmed/23984405
http://dx.doi.org/10.1155/2013/754946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745925/
https://www.ncbi.nlm.nih.gov/pubmed/23984405
http://dx.doi.org/10.1155/2013/754946

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