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Cancer metabolism meets systems biology: Pyruvate kinase isoform PKM2 is a metabolic master regulator
Pyruvate kinase activity is controlled by a tightly woven regulatory network. The oncofetal isoform of pyruvate kinase (PKM2) is a master regulator of cancer metabolism. PKM2 engages in parallel, feed-forward, positive and negative feedback control contributing to cancer progression. Besides its met...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746496/ https://www.ncbi.nlm.nih.gov/pubmed/23961261 http://dx.doi.org/10.4103/1477-3163.115423 |