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Cancer metabolism meets systems biology: Pyruvate kinase isoform PKM2 is a metabolic master regulator

Pyruvate kinase activity is controlled by a tightly woven regulatory network. The oncofetal isoform of pyruvate kinase (PKM2) is a master regulator of cancer metabolism. PKM2 engages in parallel, feed-forward, positive and negative feedback control contributing to cancer progression. Besides its met...

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Detalles Bibliográficos
Autor principal:	Filipp, Fabian V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2013
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746496/ https://www.ncbi.nlm.nih.gov/pubmed/23961261 http://dx.doi.org/10.4103/1477-3163.115423

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