Antagonistic TNF Receptor One-Specific Antibody (ATROSAB): Receptor Binding and In Vitro Bioactivity

BACKGROUND: Selective inhibition of TNFR1 signaling holds the potential to greatly reduce the pro-inflammatory activity of TNF, while leaving TNFR2 untouched, thus allowing for cell survival and tissue homeostasis. ATROSAB is a humanized antagonistic anti-TNFR1 antibody developed for the treatment o...

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Detalles Bibliográficos
Autores principales: Richter, Fabian, Liebig, Timo, Guenzi, Eric, Herrmann, Andreas, Scheurich, Peter, Pfizenmaier, Klaus, Kontermann, Roland E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747052/
https://www.ncbi.nlm.nih.gov/pubmed/23977237
http://dx.doi.org/10.1371/journal.pone.0072156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747052/
https://www.ncbi.nlm.nih.gov/pubmed/23977237
http://dx.doi.org/10.1371/journal.pone.0072156

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