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A Tumor-Penetrating Peptide Modification Enhances the Antitumor Activity of Thymosin Alpha 1
A serious limitation of numerous antitumor drugs is the incapacity to penetrate solid tumors. However, addition of an RGD fragment to peptide drugs might solve this problem. In this study, we explored whether the introduction of a permeability-enhancing sequence, such as iRGD (CRGDK/RGPD/EC) fragmen...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747120/ https://www.ncbi.nlm.nih.gov/pubmed/23977262 http://dx.doi.org/10.1371/journal.pone.0072242 |