An In-Depth Characterization of the Major Psoriasis Susceptibility Locus Identifies Candidate Susceptibility Alleles within an HLA-C Enhancer Element

Psoriasis is an immune-mediated skin disorder that is inherited as a complex genetic trait. Although genome-wide association scans (GWAS) have identified 36 disease susceptibility regions, more than 50% of the genetic variance can be attributed to a single Major Histocompatibility Complex (MHC) locu...

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Detalles Bibliográficos
Autores principales: Clop, Alex, Bertoni, Anna, Spain, Sarah L., Simpson, Michael A., Pullabhatla, Venu, Tonda, Raul, Hundhausen, Christian, Di Meglio, Paola, De Jong, Pieter, Hayday, Adrian C., Nestle, Frank O., Barker, Jonathan N., Bell, Robert J. A., Capon, Francesca, Trembath, Richard C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747202/
https://www.ncbi.nlm.nih.gov/pubmed/23990973
http://dx.doi.org/10.1371/journal.pone.0071690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747202/
https://www.ncbi.nlm.nih.gov/pubmed/23990973
http://dx.doi.org/10.1371/journal.pone.0071690

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