A Missing PD-L1/PD-1 Coinhibition Regulates Diabetes Induction by Preproinsulin-Specific CD8 T-Cells in an Epitope-Specific Manner

Coinhibitory PD-1/PD-L1 (B7-H1) interactions provide critical signals for the regulation of autoreactive T-cell responses. We established mouse models, expressing the costimulator molecule B7.1 (CD80) on pancreatic beta cells (RIP-B7.1 tg mice) or are deficient in coinhibitory PD-L1 or PD-1 molecule...

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Detalles Bibliográficos
Autores principales: Schuster, Cornelia, Brosi, Helen, Stifter, Katja, Boehm, Bernhard O., Schirmbeck, Reinhold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747217/
https://www.ncbi.nlm.nih.gov/pubmed/23977133
http://dx.doi.org/10.1371/journal.pone.0071746

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747217/
https://www.ncbi.nlm.nih.gov/pubmed/23977133
http://dx.doi.org/10.1371/journal.pone.0071746

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