Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A

Anaphase central spindle formation is controlled by the microtubule-stabilizing factor PRC1 and the kinesin KIF4A. We show that an MKlp2-dependent pool of Aurora B at the central spindle, rather than global Aurora B activity, regulates KIF4A accumulation at the central spindle. KIF4A phosphorylation...

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Detalles Bibliográficos
Autores principales: Nunes Bastos, Ricardo, Gandhi, Sapan R., Baron, Ryan D., Gruneberg, Ulrike, Nigg, Erich A., Barr, Francis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747307/
https://www.ncbi.nlm.nih.gov/pubmed/23940115
http://dx.doi.org/10.1083/jcb.201301094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747307/
https://www.ncbi.nlm.nih.gov/pubmed/23940115
http://dx.doi.org/10.1083/jcb.201301094

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