Cargando…

Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A

Anaphase central spindle formation is controlled by the microtubule-stabilizing factor PRC1 and the kinesin KIF4A. We show that an MKlp2-dependent pool of Aurora B at the central spindle, rather than global Aurora B activity, regulates KIF4A accumulation at the central spindle. KIF4A phosphorylation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nunes Bastos, Ricardo, Gandhi, Sapan R., Baron, Ryan D., Gruneberg, Ulrike, Nigg, Erich A., Barr, Francis A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747307/ https://www.ncbi.nlm.nih.gov/pubmed/23940115 http://dx.doi.org/10.1083/jcb.201301094

Ejemplares similares

Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2
por: Gruneberg, Ulrike, et al.
Publicado: (2004)

Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2
por: Zeng, Kang, et al.
Publicado: (2010)

KIF4A and PP2A–B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle
por: Bastos, Ricardo Nunes, et al.
Publicado: (2014)

Aurora A promotes chromosome congression by activating the condensin-dependent pool of KIF4A
por: Poser, Elena, et al.
Publicado: (2019)

PP6 regulation of Aurora A–TPX2 limits NDC80 phosphorylation and mitotic spindle size
por: Sobajima, Tomoaki, et al.
Publicado: (2023)

Molecular basis of MKLP2-dependent Aurora B transport from chromatin to the anaphase central spindle
por: Serena, Michela, et al.
Publicado: (2020)

Aurora B and Kif2A control microtubule length for assembly of a functional central spindle during anaphase
por: Uehara, Ryota, et al.
Publicado: (2013)

KIF14 and citron kinase act together to promote efficient cytokinesis
por: Gruneberg, Ulrike, et al.
Publicado: (2006)

GTSE1 regulates spindle microtubule dynamics to control Aurora B kinase and Kif4A chromokinesin on chromosome arms
por: Tipton, Aaron R., et al.
Publicado: (2017)

Human TPX2 is required for targeting Aurora-A kinase to the spindle
por: Kufer, Thomas A., et al.
Publicado: (2002)

Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation
por: van Heesbeen, Roy G. H. P., et al.
Publicado: (2016)

Aurora B controls kinetochore–microtubule attachments by inhibiting Ska complex–KMN network interaction
por: Chan, Ying Wai, et al.
Publicado: (2012)

EB1 enables spindle microtubules to regulate centromeric recruitment of Aurora B
por: Banerjee, Budhaditya, et al.
Publicado: (2014)

Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation
por: Dunsch, Anja K., et al.
Publicado: (2012)

Caenorhabditis elegans Aurora A kinase is required for the formation of spindle microtubules in female meiosis
por: Sumiyoshi, Eisuke, et al.
Publicado: (2015)

PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing
por: Espert, Antonio, et al.
Publicado: (2014)

DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement
por: Jang, Chang-Young, et al.
Publicado: (2008)

Localized Aurora B activity spatially controls non-kinetochore microtubules during spindle assembly
por: Tanenbaum, Marvin E., et al.
Publicado: (2011)

Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces
por: Asteriti, Italia A, et al.
Publicado: (2011)

SKAP interacts with Aurora B to guide end-on capture of spindle microtubules via phase separation
por: Zhang, Manjuan, et al.
Publicado: (2021)

The astrin–kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment
por: Dunsch, Anja K., et al.
Publicado: (2011)

KIF18A's neck linker permits navigation of microtubule-bound obstacles within the mitotic spindle
por: Malaby, Heidi LH, et al.
Publicado: (2019)

Aurora B helps the central spindle measure up
por: Short, Ben
Publicado: (2013)

MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling
por: Alfonso-Pérez, Tatiana, et al.
Publicado: (2019)

Microtubule end tethering of a processive kinesin-8 motor Kif18b is required for spindle positioning
por: McHugh, Toni, et al.
Publicado: (2018)

Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle
por: Hochegger, Helfrid, et al.
Publicado: (2013)

The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle
por: Welburn, Julie P. I., et al.
Publicado: (2012)

Overexpression of Aurora-C interferes with the spindle checkpoint by promoting the degradation of Aurora-B
por: Lin, B-W, et al.
Publicado: (2014)

The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo
por: Gruneberg, Ulrike, et al.
Publicado: (2002)

The BEG (PP2A-B55/ENSA/Greatwall) Pathway Ensures Cytokinesis follows Chromosome Separation
por: Cundell, Michael J., et al.
Publicado: (2013)

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint
por: Hauf, Silke, et al.
Publicado: (2003)

Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis
por: Recino, Asha, et al.
Publicado: (2010)

Ipl1/Aurora-dependent phosphorylation of Sli15/INCENP regulates CPC–spindle interaction to ensure proper microtubule dynamics
por: Nakajima, Yuko, et al.
Publicado: (2011)

Microtubule-sliding modules based on kinesins EG5 and PRC1-dependent KIF4A drive human spindle elongation
por: Vukušić, Kruno, et al.
Publicado: (2021)

KIF5B modulates central spindle organization in late-stage cytokinesis in chondrocytes
por: Gan, Huiyan, et al.
Publicado: (2019)

Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics
por: Hégarat, Nadia, et al.
Publicado: (2011)

Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity
por: Thein, Kerstin H., et al.
Publicado: (2007)

Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells
por: Hooikaas, Peter Jan, et al.
Publicado: (2020)

The Ska complex promotes Aurora B activity to ensure chromosome biorientation
por: Redli, Patrick M., et al.
Publicado: (2016)

KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling
por: Pejskova, Petra, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3htpqdltk6ltqbvams9bv7eoej