Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase

Streptococcus pneumoniae causes bacterial pneumonia with high mortality and morbidity. The emergency of multidrug-resistant bacteria threatens the treatment of the disease. Leucyl-tRNA synthetase (LeuRS) plays an essential role in cellular translation and is an attractive drug target for antimicrobi...

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Detalles Bibliográficos
Autores principales: Hu, Qing-Hua, Liu, Ru-Juan, Fang, Zhi-Peng, Zhang, Jiong, Ding, Ying-Ying, Tan, Min, Wang, Meng, Pan, Wei, Zhou, Hu-Chen, Wang, En-Duo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747510/
https://www.ncbi.nlm.nih.gov/pubmed/23959225
http://dx.doi.org/10.1038/srep02475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747510/
https://www.ncbi.nlm.nih.gov/pubmed/23959225
http://dx.doi.org/10.1038/srep02475

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