A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K(2P) Channels

[Image: see text] K(2P) (KCNK) potassium channels generate “leak” potassium currents that strongly influence cellular excitability and contribute to pain, somatosensation, anesthesia, and mood. Despite their physiological importance, K(2P)s lack specific pharmacology. Addressing this issue has been...

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Detalles Bibliográficos
Autores principales: Bagriantsev, Sviatoslav N., Ang, Kean-Hooi, Gallardo-Godoy, Alejandra, Clark, Kimberly A., Arkin, Michelle R., Renslo, Adam R., Minor, Daniel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747594/
https://www.ncbi.nlm.nih.gov/pubmed/23738709
http://dx.doi.org/10.1021/cb400289x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747594/
https://www.ncbi.nlm.nih.gov/pubmed/23738709
http://dx.doi.org/10.1021/cb400289x

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