Human APOBEC3A Isoforms Translocate to the Nucleus and Induce DNA Double Strand Breaks Leading to Cell Stress and Death

Human APOBEC3 enzymes deaminate single stranded DNA. At least five can deaminate mitochondrial DNA in the cytoplasm, while three can deaminate viral DNA in the nucleus. However, only one, APOBEC3A, can hypermutate genomic DNA. We analysed the distribution and function of the two APOBEC3A isoforms p1...

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Detalles Bibliográficos
Autores principales: Mussil, Bianka, Suspène, Rodolphe, Aynaud, Marie-Ming, Gauvrit, Anne, Vartanian, Jean-Pierre, Wain-Hobson, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748023/
https://www.ncbi.nlm.nih.gov/pubmed/23977391
http://dx.doi.org/10.1371/journal.pone.0073641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748023/
https://www.ncbi.nlm.nih.gov/pubmed/23977391
http://dx.doi.org/10.1371/journal.pone.0073641

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