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The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist
Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol induces NO production remains unknown, resulting in the genesis of much of the controversy regarding the pharmacological action...
Autores principales: | Erickson, Catherine E., Gul, Rukhsana, Blessing, Christopher P., Nguyen, Jenny, Liu, Tammy, Pulakat, Lakshmi, Bastepe, Murat, Jackson, Edwin K., Andresen, Bradley T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748024/ https://www.ncbi.nlm.nih.gov/pubmed/23977191 http://dx.doi.org/10.1371/journal.pone.0071980 |
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