Imbalance between HAT and HDAC Activities in the PBMCs of Patients with Ankylosing Spondylitis or Rheumatoid Arthritis and Influence of HDAC Inhibitors on TNF Alpha Production

OBJECTIVE: Acetylation or deacetylation of histone proteins may modulate cytokine gene transcription such as TNF alpha (TNF). We evaluated the balance between histone deacetytlase (HDAC) and histone acetyltransferase (HAT) in patients with rheumatoid arthritis (RA) or ankylosing spondylitis (AS) com...

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Detalles Bibliográficos
Autores principales: Toussirot, Eric, Abbas, Wasim, Khan, Kashif Aziz, Tissot, Marion, Jeudy, Alicia, Baud, Lucile, Bertolini, Ewa, Wendling, Daniel, Herbein, Georges
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748901/
https://www.ncbi.nlm.nih.gov/pubmed/24039666
http://dx.doi.org/10.1371/journal.pone.0070939

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748901/
https://www.ncbi.nlm.nih.gov/pubmed/24039666
http://dx.doi.org/10.1371/journal.pone.0070939

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