Cargando…

Imbalance between HAT and HDAC Activities in the PBMCs of Patients with Ankylosing Spondylitis or Rheumatoid Arthritis and Influence of HDAC Inhibitors on TNF Alpha Production

OBJECTIVE: Acetylation or deacetylation of histone proteins may modulate cytokine gene transcription such as TNF alpha (TNF). We evaluated the balance between histone deacetytlase (HDAC) and histone acetyltransferase (HAT) in patients with rheumatoid arthritis (RA) or ankylosing spondylitis (AS) com...

Descripción completa

Detalles Bibliográficos
Autores principales:	Toussirot, Eric, Abbas, Wasim, Khan, Kashif Aziz, Tissot, Marion, Jeudy, Alicia, Baud, Lucile, Bertolini, Ewa, Wendling, Daniel, Herbein, Georges
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748901/ https://www.ncbi.nlm.nih.gov/pubmed/24039666 http://dx.doi.org/10.1371/journal.pone.0070939

Ejemplares similares

Management of ankylosing spondylitis with infliximab
por: Toussirot, Éric, et al.
Publicado: (2009)

Sirtuin 1 Activity in Peripheral Blood Mononuclear Cells of Patients with Osteoporosis
por: Godfrin-Valnet, Marie, et al.
Publicado: (2014)

Small Molecules Targeting HATs, HDACs, and BRDs in Cancer Therapy
por: Wu, Donglu, et al.
Publicado: (2020)

HAT- and HDAC-Targeted Protein Acetylation in the Occurrence and Treatment of Epilepsy
por: Wang, Jie, et al.
Publicado: (2022)

Physical and Functional HAT/HDAC Interplay Regulates Protein Acetylation Balance
por: Peserico, Alessia, et al.
Publicado: (2011)

Serum Adipokines and Adipose Tissue Distribution in Rheumatoid Arthritis and Ankylosing Spondylitis. A Comparative Study
por: Toussirot, Éric, et al.
Publicado: (2013)

HDAC1 regulates inflammation and osteogenic differentiation of ankylosing spondylitis fibroblasts through the Wnt-Smad signaling pathway
por: Zeng, Yong, et al.
Publicado: (2022)

T lymphocyte subset imbalances in patients contribute to ankylosing spondylitis
por: WANG, CHENGGONG, et al.
Publicado: (2015)

Resveratrol, a sirtuin 1 activator, increases IL-6 production by peripheral blood mononuclear cells of patients with knee osteoarthritis
por: Wendling, Daniel, et al.
Publicado: (2013)

Anti-TNF-α Therapy for Ankylosing Spondylitis
por: Son, Jung-Hwan, et al.
Publicado: (2010)

Decreased Histone Deacetylase 2 (HDAC2) in Peripheral Blood Monocytes (PBMCs) of COPD Patients
por: Tan, Chunting, et al.
Publicado: (2016)

Short communication: TNF-α and IGF-1 regulates epigenetic mechanisms of HDAC2 and HDAC10
por: Jiang, Wanlin, et al.
Publicado: (2022)

TNF and TNF Receptor Superfamily Members in HIV infection: New Cellular Targets for Therapy?
por: Kumar, Amit, et al.
Publicado: (2013)

TNF-alpha antagonists for treatment of juvenile ankylosing spondylitis
por: Orbán, I, et al.
Publicado: (2011)

HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors
por: Zammataro, Magda, et al.
Publicado: (2014)

Cloning and Expression Analysis of HAT1 and HDAC1 in the Testes of Mature Yaks and Their Sterile Hybrids
por: Sun, Shijie, et al.
Publicado: (2022)

Histone deacetylase inhibitors: a new and promising drug class for the treatment of arthritis?
por: Toussirot, Éric, et al.
Publicado: (2010)

Expression of Histone Deacetylases HDAC1, HDAC2, HDAC3, and HDAC6 in Invasive Ductal Carcinomas of the Breast
por: Seo, Jinwon, et al.
Publicado: (2014)

Clinicopathological features and prediction values of HDAC1, HDAC2, HDAC3, and HDAC11 in classical Hodgkin lymphoma
por: Huang, Renhong, et al.
Publicado: (2018)

Imbalance of Peripheral Lymphocyte Subsets in Patients With Ankylosing Spondylitis: A Meta-Analysis
por: Liu, Dong, et al.
Publicado: (2021)

Dysregulated Serum IL-23 and SIRT1 Activity in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis
por: Wendling, Daniel, et al.
Publicado: (2015)

Blood HDAC4 Variation Links With Disease Activity and Response to Tumor Necrosis Factor Inhibitor and Regulates CD4+ T Cell Differentiation in Ankylosing Spondylitis
por: Dou, Bin, et al.
Publicado: (2022)

Involvement of HDAC1 and HDAC3 in the Pathology of Polyglutamine Disorders: Therapeutic Implications for Selective HDAC1/HDAC3 Inhibitors
por: Thomas, Elizabeth A.
Publicado: (2014)

Inhibition of HDAC6 Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy
por: Abouhish, Hossameldin, et al.
Publicado: (2020)

Chromatin and transcriptomic profiling uncover dysregulation of the Tip60 HAT/HDAC2 epigenomic landscape in the neurodegenerative brain
por: Beaver, Mariah, et al.
Publicado: (2021)

Ankylosing spondylitis
Publicado: (1980)

Ankylosing spondylitis
por: Edavalath, Mukesh
Publicado: (2010)

Ankylosing Spondylitis
por: Whitfield, A. G. W.
Publicado: (1976)

Ankylosing Spondylitis
por: Ebrahimiadib, Nazanin, et al.
Publicado: (2021)

Serum Metabolomics Signatures Associated With Ankylosing Spondylitis and TNF Inhibitor Therapy
por: Ou, Jiayong, et al.
Publicado: (2021)

HDAC and HDAC Inhibitor: From Cancer to Cardiovascular Diseases
por: Yoon, Somy, et al.
Publicado: (2016)

HDAC1 and HDAC2 Modulate TGF-β Signaling during Endothelial-to-Hematopoietic Transition
por: Thambyrajah, Roshana, et al.
Publicado: (2018)

Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites
por: Yasuda, Takeshi, et al.
Publicado: (2018)

HDAC3 and HDAC8 are required for cilia assembly and elongation
por: Park, Seon-ah, et al.
Publicado: (2019)

Metabolism, HDACs, and HDAC Inhibitors: A Systems Biology Perspective
por: King, Jacob, et al.
Publicado: (2021)

TNF-α inhibitor therapy can improve the immune imbalance of CD4+ T cells and negative regulatory cells but not CD8+ T cells in ankylosing spondylitis
por: Yang, Mingcan, et al.
Publicado: (2020)

Reparative radiological changes of hip joint after TNF inhibitors in ankylosing spondylitis
por: Maatallah, Kaouther, et al.
Publicado: (2018)

Machine learning to predict early TNF inhibitor users in patients with ankylosing spondylitis
por: Lee, Seulkee, et al.
Publicado: (2020)

Association of anti-TNF-α treatment with gut microbiota of patients with ankylosing spondylitis
por: Dai, Qinghong, et al.
Publicado: (2022)

Expression levels of the microRNA maturing microprocessor complex components; Drosha, Dicer, and DGCR8 in PBMCs from ankylosing spondylitis patients
por: Tabrizi, Zeinab, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_7rkm7mbcl46r1g685np9o5vjef