The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo glioma growth irrespective of EGF receptor status

BACKGROUND: Deregulated growth factor signaling is a major driving force in the initiation and progression of glioblastoma. The tumor suppressor and stem cell marker Lrig1 is a negative regulator of the epidermal growth factor receptor (EGFR) family. Here, we addressed the therapeutic potential of t...

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Detalles Bibliográficos
Autores principales: Johansson, Mikael, Oudin, Anaïs, Tiemann, Katja, Bernard, Amandine, Golebiewska, Anna, Keunen, Olivier, Fack, Fred, Stieber, Daniel, Wang, Baofeng, Hedman, Håkan, Niclou, Simone P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748912/
https://www.ncbi.nlm.nih.gov/pubmed/23723255
http://dx.doi.org/10.1093/neuonc/not054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748912/
https://www.ncbi.nlm.nih.gov/pubmed/23723255
http://dx.doi.org/10.1093/neuonc/not054

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