In silico identification of EGFR-T790M inhibitors with novel scaffolds: start with extraction of common features

BACKGROUND: Epidermal growth factor receptor (EGFR) is an attractive therapeutic target for a number of human tumors including non-small cell lung cancer (NSCLC). Most patients with NSCLC and somatic mutations have shown a dramatic initial clinical response to reversible EGFR inhibitors. The clinica...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiang, Mingli, Lei, Kai, Fan, Wenjie, Lin, Yuchun, He, Gu, Yang, Mingli, Chen, Lijuan, Mo, Yirong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748928/
https://www.ncbi.nlm.nih.gov/pubmed/23990708
http://dx.doi.org/10.2147/DDDT.S41305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748928/
https://www.ncbi.nlm.nih.gov/pubmed/23990708
http://dx.doi.org/10.2147/DDDT.S41305

Ejemplares similares