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Unique Transcriptional Profile of Sustained Ligand-Activated Preconditioning in Pre- and Post-Ischemic Myocardium

BACKGROUND: Opioidergic SLP (sustained ligand-activated preconditioning) induced by 3–5 days of opioid receptor (OR) agonism induces persistent protection against ischemia-reperfusion (I-R) injury in young and aged hearts, and is mechanistically distinct from conventional preconditioning responses....

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Detalles Bibliográficos
Autores principales: Ashton, Kevin J., Tupicoff, Amanda, Williams-Pritchard, Grant, Kiessling, Can J., See Hoe, Louise E., Headrick, John P., Peart, Jason N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749099/
https://www.ncbi.nlm.nih.gov/pubmed/23991079
http://dx.doi.org/10.1371/journal.pone.0072278