Theoretical Predictions of Lactate and Hydrogen Ion Distributions in Tumours

High levels of lactate and H(+)-ions play an important role in the invasive and metastatic cascade of some tumours. We develop a mathematical model of cellular pH regulation focusing on the activity of the Na(+)/H(+) exchanger (NHE) and the lactate/H(+) symporter (MCT) to investigate the spatial cor...

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Detalles Bibliográficos
Autores principales: Al-Husari, Maymona, Webb, Steven D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749110/
https://www.ncbi.nlm.nih.gov/pubmed/23991029
http://dx.doi.org/10.1371/journal.pone.0072020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749110/
https://www.ncbi.nlm.nih.gov/pubmed/23991029
http://dx.doi.org/10.1371/journal.pone.0072020

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