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Theoretical Predictions of Lactate and Hydrogen Ion Distributions in Tumours
High levels of lactate and H(+)-ions play an important role in the invasive and metastatic cascade of some tumours. We develop a mathematical model of cellular pH regulation focusing on the activity of the Na(+)/H(+) exchanger (NHE) and the lactate/H(+) symporter (MCT) to investigate the spatial cor...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749110/ https://www.ncbi.nlm.nih.gov/pubmed/23991029 http://dx.doi.org/10.1371/journal.pone.0072020 |