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STAT3 or USF2 Contributes to HIF Target Gene Specificity

The HIF1- and HIF2-mediated transcriptional responses play critical roles in solid tumor progression. Despite significant similarities, including their binding to promoters of both HIF1 and HIF2 target genes, HIF1 and HIF2 proteins activate unique subsets of target genes under hypoxia. The mechanism...

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Detalles Bibliográficos
Autores principales: Pawlus, Matthew R., Wang, Liyi, Murakami, Aya, Dai, Guanhai, Hu, Cheng-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749168/
https://www.ncbi.nlm.nih.gov/pubmed/23991099
http://dx.doi.org/10.1371/journal.pone.0072358