Distinct Phenotypic Differences Associated with Differential Amplification of Receptor Tyrosine Kinase Genes at 4q12 in Glioblastoma

Gene amplification at chromosome 4q12 is a common alteration in human high grade gliomas including glioblastoma, a CNS tumour with consistently poor prognosis. This locus harbours the known oncogenes encoding the receptor tyrosine kinases PDGFRA, KIT, and VEGFR2. These receptors are potential target...

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Detalles Bibliográficos
Autores principales: Burford, Anna, Little, Suzanne E., Jury, Alexa, Popov, Sergey, Laxton, Ross, Doey, Lawrence, Al-Sarraj, Safa, Jürgensmeier, Juliane M., Jones, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749194/
https://www.ncbi.nlm.nih.gov/pubmed/23990986
http://dx.doi.org/10.1371/journal.pone.0071777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749194/
https://www.ncbi.nlm.nih.gov/pubmed/23990986
http://dx.doi.org/10.1371/journal.pone.0071777

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