Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling

Oxysterols bind the seven-spanner transmembrane protein Smoothened and potently activate vertebrate Hedgehog signaling, a pathway essential in embryonic development, adult stem cell maintenance and cancer. It is unknown, however, if oxysterols are important for normal vertebrate Hedgehog signaling,...

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Detalles Bibliográficos
Autores principales: Nedelcu, Daniel, Liu, Jing, Xu, Yangqing, Jao, Cindy, Salic, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749252/
https://www.ncbi.nlm.nih.gov/pubmed/23831757
http://dx.doi.org/10.1038/nchembio.1290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749252/
https://www.ncbi.nlm.nih.gov/pubmed/23831757
http://dx.doi.org/10.1038/nchembio.1290

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