Interleukin-18 Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice

Circulating interleukin (IL)-18 is elevated in obesity, but paradoxically causes hypophagia. We hypothesized that IL-18 may attenuate high-fat diet (HFD)-induced insulin resistance by activating AMP-activated protein kinase (AMPK). We studied mice with a global deletion of the α-isoform of the IL-18...

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Detalles Bibliográficos
Autores principales: Lindegaard, Birgitte, Matthews, Vance B., Brandt, Claus, Hojman, Pernille, Allen, Tamara L., Estevez, Emma, Watt, Matthew J., Bruce, Clinton R., Mortensen, Ole H., Syberg, Susanne, Rudnicka, Caroline, Abildgaard, Julie, Pilegaard, Henriette, Hidalgo, Juan, Ditlevsen, Susanne, Alsted, Thomas J., Madsen, Andreas N., Pedersen, Bente K., Febbraio, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749341/
https://www.ncbi.nlm.nih.gov/pubmed/23670974
http://dx.doi.org/10.2337/db12-1095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749341/
https://www.ncbi.nlm.nih.gov/pubmed/23670974
http://dx.doi.org/10.2337/db12-1095

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