Tetrahydrobiopterin Has a Glucose-Lowering Effect by Suppressing Hepatic Gluconeogenesis in an Endothelial Nitric Oxide Synthase–Dependent Manner in Diabetic Mice

Endothelial nitric oxide synthase (eNOS) dysfunction induces insulin resistance and glucose intolerance. Tetrahydrobiopterin (BH(4)) is an essential cofactor of eNOS that regulates eNOS activity. In the diabetic state, BH(4) is oxidized to 7,8-dihydrobiopterin, which leads to eNOS dysfunction owing...

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Detalles Bibliográficos
Autores principales: Abudukadier, Abulizi, Fujita, Yoshihito, Obara, Akio, Ohashi, Akiko, Fukushima, Toru, Sato, Yuichi, Ogura, Masahito, Nakamura, Yasuhiko, Fujimoto, Shimpei, Hosokawa, Masaya, Hasegawa, Hiroyuki, Inagaki, Nobuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749361/
https://www.ncbi.nlm.nih.gov/pubmed/23649519
http://dx.doi.org/10.2337/db12-1242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749361/
https://www.ncbi.nlm.nih.gov/pubmed/23649519
http://dx.doi.org/10.2337/db12-1242

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