The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations

Pulmonary arterial hypertension (PAH) is characterized by dysregulated pulmonary artery endothelial cell (PAEC) proliferation, apoptosis and permeability. Loss-of-function mutations in the bone morphogenetic protein receptor type-II (BMPR-II) are the most common cause of heritable PAH, usually resul...

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Detalles Bibliográficos
Autores principales: Dunmore, Benjamin J., Drake, Kylie M., Upton, Paul D., Toshner, Mark R., Aldred, Micheala A., Morrell, Nicholas W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749859/
https://www.ncbi.nlm.nih.gov/pubmed/23669347
http://dx.doi.org/10.1093/hmg/ddt216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749859/
https://www.ncbi.nlm.nih.gov/pubmed/23669347
http://dx.doi.org/10.1093/hmg/ddt216

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