Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells

The atherogenic cytokine IL-6 (interleukin-6) induces pro-inflammatory gene expression in VECs (vascular endothelial cells) by activating the JAK (Janus kinase)/STAT3 (signal transducer and activator of transcription 3) signalling pathway, which is normally down-regulated by the STAT3-dependent indu...

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Detalles Bibliográficos
Autores principales: Wiejak, Jolanta, Dunlop, Julia, Mackay, Simon P., Yarwood, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749869/
https://www.ncbi.nlm.nih.gov/pubmed/23782265
http://dx.doi.org/10.1042/BJ20130481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749869/
https://www.ncbi.nlm.nih.gov/pubmed/23782265
http://dx.doi.org/10.1042/BJ20130481

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