From Principal Component to Direct Coupling Analysis of Coevolution in Proteins: Low-Eigenvalue Modes are Needed for Structure Prediction

Various approaches have explored the covariation of residues in multiple-sequence alignments of homologous proteins to extract functional and structural information. Among those are principal component analysis (PCA), which identifies the most correlated groups of residues, and direct coupling analy...

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Detalles Bibliográficos
Autores principales: Cocco, Simona, Monasson, Remi, Weigt, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749948/
https://www.ncbi.nlm.nih.gov/pubmed/23990764
http://dx.doi.org/10.1371/journal.pcbi.1003176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749948/
https://www.ncbi.nlm.nih.gov/pubmed/23990764
http://dx.doi.org/10.1371/journal.pcbi.1003176

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