The Protein Kinase Double-Stranded RNA-Dependent (PKR) Enhances Protection against Disease Cause by a Non-Viral Pathogen

PKR is well characterized for its function in antiviral immunity. Using Toxoplasma gondii, we examined if PKR promotes resistance to disease caused by a non-viral pathogen. PKR(−/−) mice infected with T. gondii exhibited higher parasite load and worsened histopathology in the eye and brain compared...

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Detalles Bibliográficos
Autores principales: Ogolla, Pauline Sebby, Portillo, Jose-Andres C., White, Christine L., Patel, Krupen, Lamb, Bruce, Sen, Ganes C., Subauste, Carlos S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749959/
https://www.ncbi.nlm.nih.gov/pubmed/23990781
http://dx.doi.org/10.1371/journal.ppat.1003557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749959/
https://www.ncbi.nlm.nih.gov/pubmed/23990781
http://dx.doi.org/10.1371/journal.ppat.1003557

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