Cargando…

The Protein Kinase Double-Stranded RNA-Dependent (PKR) Enhances Protection against Disease Cause by a Non-Viral Pathogen

PKR is well characterized for its function in antiviral immunity. Using Toxoplasma gondii, we examined if PKR promotes resistance to disease caused by a non-viral pathogen. PKR(−/−) mice infected with T. gondii exhibited higher parasite load and worsened histopathology in the eye and brain compared...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ogolla, Pauline Sebby, Portillo, Jose-Andres C., White, Christine L., Patel, Krupen, Lamb, Bruce, Sen, Ganes C., Subauste, Carlos S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749959/ https://www.ncbi.nlm.nih.gov/pubmed/23990781 http://dx.doi.org/10.1371/journal.ppat.1003557

Ejemplares similares

PKR, the double stranded RNA-dependent protein kinase as a critical target in Alzheimer's disease
por: Morel, Milena, et al.
Publicado: (2009)

Activation of the Antiviral Kinase PKR and Viral Countermeasures
por: Dauber, Bianca, et al.
Publicado: (2009)

Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: Varying the number of double-stranded RNA binding domains and lineage-specific duplications
por: Rothenburg, Stefan, et al.
Publicado: (2008)

Interaction of PKR with single-stranded RNA
por: Mayo, Christopher B., et al.
Publicado: (2017)

Phosphorylable tyrosine residue 162 in the double-stranded RNA-dependent kinase PKR modulates its interaction with SUMO
por: de la Cruz-Herrera, Carlos F., et al.
Publicado: (2017)

Glycogen synthase kinase (GSK)-3 and the double-strand RNA-dependent kinase, PKR: When two kinases for the common good turn bad()
por: Piazzi, Manuela, et al.
Publicado: (2020)

Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors
por: Rothenburg, Stefan, et al.
Publicado: (2008)

PKR: A Kinase to Remember
por: Gal-Ben-Ari, Shunit, et al.
Publicado: (2019)

Activation of PKR by short stem–loop RNAs containing single-stranded arms
por: Mayo, Christopher B., et al.
Publicado: (2016)

Viral Evolved Inhibition Mechanism of the RNA Dependent Protein Kinase PKR's Kinase Domain, a Structural Perspective
por: Krishna, K. Hari, et al.
Publicado: (2016)

Direct Activation of Ribosome-Associated Double-Stranded RNA-Dependent Protein Kinase (PKR) by Deoxynivalenol, Anisomycin and Ricin: A New Model for Ribotoxic Stress Response Induction
por: Zhou, Hui-Ren, et al.
Publicado: (2014)

Oncogenes: The Passport for Viral Oncolysis Through PKR Inhibition
por: Fernandes, Janaina
Publicado: (2016)

PKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs
por: Cesaro, Teresa, et al.
Publicado: (2021)

PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis
por: Kapil, Parul, et al.
Publicado: (2014)

NIPBL Controls RNA Biogenesis to Prevent Activation of the Stress Kinase PKR
por: Yuen, Kobe C., et al.
Publicado: (2015)

Viral evasion of PKR restriction by reprogramming cellular stress granules
por: Gao, Peng, et al.
Publicado: (2022)

Ginsenoside Rb1 from Panax notoginseng Suppressed TNF-α-Induced Matrix Metalloproteinase-9 via the Suppression of Double-Strand RNA-Dependent Protein Kinase (PKR)/NF-κB Pathway
por: Sun, Wen-Tao, et al.
Publicado: (2022)

Characterization of a ranavirus inhibitor of the antiviral protein kinase PKR
por: Rothenburg, Stefan, et al.
Publicado: (2011)

The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication
por: Clerzius, Guerline, et al.
Publicado: (2013)

Inhibition of PKR by Viruses
por: Cesaro, Teresa, et al.
Publicado: (2021)

The Roles of Two IκB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection
por: Hemmi, Hiroaki, et al.
Publicado: (2004)

PKR-Like Endoplasmic Reticulum Kinase Is Necessary for Lipogenic Activation during HCMV Infection
por: Yu, Yongjun, et al.
Publicado: (2013)

PKR-like ER kinase (PERK) Haplotypes Are Associated with Depressive Symptoms in People with HIV
por: Haddadi, S, et al.
Publicado: (2023)

Positive Regulation of Splicing of Cellular and Viral mRNA by Intragenic RNA Elements That Activate the Stress Kinase PKR, an Antiviral Mechanism
por: Kaempfer, Raymond
Publicado: (2023)

Diversity in Viral Anti-PKR Mechanisms: A Remarkable Case of Evolutionary Convergence
por: Domingo-Gil, Elena, et al.
Publicado: (2011)

PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation
por: Farabaugh, Kenneth T, et al.
Publicado: (2020)

Influenza B Virus Ribonucleoprotein Is a Potent Activator of the Antiviral Kinase PKR
por: Dauber, Bianca, et al.
Publicado: (2009)

Signaling by the integrated stress response kinase PKR is fine-tuned by dynamic clustering
por: Zappa, Francesca, et al.
Publicado: (2022)

PKR involvement in Alzheimer’s disease
por: Hugon, Jacques, et al.
Publicado: (2017)

Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR
por: Mittelstadt, Megan, et al.
Publicado: (2008)

Role of PKR and Type I IFNs in Viral Control during Primary and Secondary Infection
por: Nakayama, Yumi, et al.
Publicado: (2010)

KSHV inhibits stress granule formation by viral ORF57 blocking PKR activation
por: Sharma, Nishi R., et al.
Publicado: (2017)

eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition
por: Wuerth, Jennifer Deborah, et al.
Publicado: (2020)

Epidermal growth factor receptor promotes cerebral and retinal invasion by Toxoplasma gondii
por: Corcino, Yalitza Lopez, et al.
Publicado: (2019)

PKR kinase directly regulates tau expression and Alzheimer's disease‐related tau phosphorylation
por: Reimer, Lasse, et al.
Publicado: (2020)

Silencing of viral RNAs by small double-stranded siDNA
por: Moelling, Karin, et al.
Publicado: (2009)

RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer
por: Guo, Chengcheng, et al.
Publicado: (2015)

A cell‐penetrating CD40‐TRAF2,3 blocking peptide diminishes inflammation and neuronal loss after ischemia/reperfusion
por: Portillo, Jose‐Andres C., et al.
Publicado: (2021)

The radioresistance kinase TLK1B protects the cells by promoting repair of double strand breaks
por: Sunavala-Dossabhoy, Gulshan, et al.
Publicado: (2005)

LincRNA‐EPS impairs host antiviral immunity by antagonizing viral RNA–PKR interaction
por: Zhu, Jingfei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_v90uo2cn8u2js269f3v54ktjmb