A New Class of Rhomboid Protease Inhibitors Discovered by Activity-Based Fluorescence Polarization

Rhomboids are intramembrane serine proteases that play diverse biological roles, including some that are of potential therapeutical relevance. Up to date, rhomboid inhibitor assays are based on protein substrate cleavage. Although rhomboids have an overlapping substrate specificity, substrates canno...

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Detalles Bibliográficos
Autores principales: Wolf, Eliane V., Zeißler, Annett, Vosyka, Oliver, Zeiler, Evelyn, Sieber, Stephan, Verhelst, Steven H. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750051/
https://www.ncbi.nlm.nih.gov/pubmed/23991088
http://dx.doi.org/10.1371/journal.pone.0072307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750051/
https://www.ncbi.nlm.nih.gov/pubmed/23991088
http://dx.doi.org/10.1371/journal.pone.0072307

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