Cargando…
A New Class of Rhomboid Protease Inhibitors Discovered by Activity-Based Fluorescence Polarization
Rhomboids are intramembrane serine proteases that play diverse biological roles, including some that are of potential therapeutical relevance. Up to date, rhomboid inhibitor assays are based on protein substrate cleavage. Although rhomboids have an overlapping substrate specificity, substrates canno...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750051/ https://www.ncbi.nlm.nih.gov/pubmed/23991088 http://dx.doi.org/10.1371/journal.pone.0072307 |