Depletion of Retinoic Acid Receptors Initiates a Novel Positive Feedback Mechanism that Promotes Teratogenic Increases in Retinoic Acid

Normal embryonic development and tissue homeostasis require precise levels of retinoic acid (RA) signaling. Despite the importance of appropriate embryonic RA signaling levels, the mechanisms underlying congenital defects due to perturbations of RA signaling are not completely understood. Here, we r...

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Detalles Bibliográficos
Autores principales: D'Aniello, Enrico, Rydeen, Ariel B., Anderson, Jane L., Mandal, Amrita, Waxman, Joshua S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750112/
https://www.ncbi.nlm.nih.gov/pubmed/23990796
http://dx.doi.org/10.1371/journal.pgen.1003689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750112/
https://www.ncbi.nlm.nih.gov/pubmed/23990796
http://dx.doi.org/10.1371/journal.pgen.1003689

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